Topical Clindamycin phosphate and benzoyl peroxide Benzoyl peroxide are considered one of the most potent topical antibiotics. It also has a mild drying effect that allows excess oil and dirt to be washed away. Not for use in childrens under 12 years of age. Clindamycin is an antibiotic that prevents bacteria from growing on the skin. It is a very common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus (MRSA) infections. The combination of benzoyl peroxide with clindamycin makes a potent topical antibiotic which is available both through prescription or over-the-counter. A single-blind study comparing this combination to a retinoid (vit A based treatment), also found it to work faster as well as more effective. Side effects may include severe redness, burning, stinging, or peeling of treated skin areas; or diarrhea that is watery or bloody. Tell your doctor if you are using other antiobiotics like oral or topical erythromycin.